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ISSN 2093-6966(Print), ISSN 2234-6856(Online) Journal of Pharmacopuncture 2013;16(two):028-032 DOI: dx.doi.org/10.3831/KPI.2013.16.Original Articletoxicity test, LD50, injectionObjective: This study was performed to analyze the single-dose toxicity of D-amino acid oxidase (DAAO) extracts. Solutions: All experiments were carried out at the Korea Testing Study Institute (KTR), an institution authorized to carry out non-clinical research, beneath the regulations of Good Laboratory Practice (GLP). Sprague-Dawley rats had been chosen for the pilot study. Doses of DAAO extracts, 0.1 to 0.three cc, were administered for the experimental group, plus the exact same doses of regular saline solution have been administered for the handle group. This study was performed beneath the approval in the Institutional Animal Ethics Committee. Outcomes: In all 4 groups, no deaths occurred, and theReceived: Apr 15,Accepted: Apr 23,LD50 of DAAO extracts administered by IV was over 0.three ml/kg. No substantial adjustments inside the weight amongst the manage group and the experimental group had been observed. To check for abnormalities in organs and tissues, we made use of microscopy to examine representative histological sections of every single specified organ, the outcomes showed no important variations in any organs or tissues. Conclusion: The above findings recommend that remedy with D-amino acid oxidase extracts is relatively protected. NOP Receptor/ORL1 Agonist supplier Additional studies on this subject really should be conducted to yield a lot more concrete proof.D-amino acid oxidase (DAAO) is actually a peroxisomal enzyme containing flavin adenine dinucleotide (FAD) as a cofactor and is within a wide selection of species fromThis is an Open-Access short article distributed beneath the terms with the Inventive Commons Attribution Non-Commercial License (TLR7 Agonist Compound creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, offered the original operate is correctly cited. This paper meets the needs of KS X ISO 9706, ISO 9706-199.
