ATN1 Antibody Summary
| Immunogen |
The immunogen recognized by this antibody maps to a region between residue 1100 and 1150 of human Atrophin 1 using the numbering given in entry NP_001007027.1 (GeneID 1822 ).
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
ATN1
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Human
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for ATN1 Antibody
- ATN1
- atrophin 1
- atrophin-1
- B37
- D12S755E
- dentatorubral-pallidoluysian atrophy (atrophin-1)
- Dentatorubral-pallidoluysian atrophy protein
- DRPLA
- DRPLANOD
- HRS
- NOD
Background
Dentatorubral pallidoluysian atrophy is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion of a trinucleotide repeat within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein.
