Product: Metoclopramide (hydrochloride hydrate)
Adrenomedullin R/ADMR/GPR182 Antibody Summary
| Immunogen |
Synthetic 18 amino acid peptide from C-terminus of human GPR182 / ADMR.
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| Specificity |
Human GPR182 / ADMR. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
GPR182
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Gorila (100%), Gibbon (100%), Marmoset (89%), Bovine (89%), Equine (89%), Elephant (83%), Rabbit (83%), Porcine (83%).
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.1% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Adrenomedullin R/ADMR/GPR182 Antibody
- 7TMR
- ADMR
- Adrenomedullin R
- adrenomedullin receptor
- AdrenomedullinR
- AMR
- AM-R
- G protein-coupled receptor 182,7TMR
- G10D
- GAMRH
- Gpcr17
- Gpcr22
- GPR182
- G-protein coupled receptor 182
- hrhAMR
- MB10
- MGC34399
- NOW
Background
G Protein-Coupled Receptor L1/G10D (GPR182) has been suggested to be an Adrenomedullin Receptor. Originally cloned from rats and later from humans, L1/G10D does not to bind adrenomedullin or display functional cAMP response to adrenomedullin (reviewed in Poyner et al. 2002). The initial experimental results, which demonstrated high-affinity binding and increased levels of cAMP in COS cells that were transfected with L1/G10D and treated with adrenomedullin, could not be reproduced by other laboratories (Kapas et al. 1995). It is now known that the functional adrenomedullin receptor is a heterodimeric complex composed of calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) (McLatchie et al. 1998). L1/G10D therefore should be considered an Orphan A receptor.
