Axl Antibody (1B3A2) Summary
| Immunogen |
Purified recombinant fragment of AXL(aa466-530) expressed in E. Coli.
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
AXL
|
| Purity |
Unpurified
|
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|
Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Ascites
|
| Preservative |
0.03% Sodium Azide
|
| Purity |
Unpurified
|
Alternate Names for Axl Antibody (1B3A2)
- Ark
- AXL oncogene
- AXL receptor tyrosine kinase
- AXL transforming sequence/gene
- Axl
- EC 2.7.10
- EC 2.7.10.1
- JTK11
- tyrosine-protein kinase receptor UFO
- Ufo
- UFOoncogene AXL
Background
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduce signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K dependent protein growth arrest specific gene 6. It is involved in the stimulation of cell proliferation. This receptor can also mediate cell aggregation by homophilic binding. Axl is a chronic myelogenous leukemia associated oncogene and also associated with colon cancer and melanoma. It is in close vicinity to the bcl3 oncogene which is at 19q13.1-q13.2. The Axl gene is evolutionarily conserved between vertebrate species. This gene has two different alternatively spliced transcript variants (AXL1 and AXL2).
