BBS4 Antibody Summary
| Immunogen |
Peptide with sequence C-NEAAKLNQKDWEISH corresponding to internal region according to NP_149017.2.
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| Epitope |
C-NEAAKLNQKDWEISH
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
BBS4
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Approx. 60 kDa band observed in HeLa lysates (calculated MW of 58.3 kDa band according to NP_149017.2).
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Mouse, Rat, Canine, Porcine, Bovine.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
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| Preservative |
0.02% Sodium Azide
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| Purity |
Immunogen affinity purified
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Alternate Names for BBS4 Antibody
- Bardet-Biedl syndrome 4 protein
- Bardet-Biedl syndrome 4
Background
This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by severe pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse. The similar phenotypes exhibited by mutations in BBS gene family members are likely due to the proteins shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene has sequence similarity to O-linked N-acetylglucosamine (O-GlcNAc) transferases in plants and archaebacteria and in human forms a multi-protein “BBSome” complex with six other BBS proteins. Alternative splice variants have been described but their predicted protein products have not been experimentally verified.
