BID [p Ser78] Antibody Summary
| Immunogen |
The immunogen recognized by this antibody maps to phosphorylated Serine 78 and surrounding residues mouse BH3 interacting domain death agonist using the numbering given in entry NP_031570.2 (GeneID 12122).
|
| Modification |
p Ser78
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
BID
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Mouse
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
0.5 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for BID [p Ser78] Antibody
- apoptic death agonist
- BH3 interacting domain death agonist
- BH3-interacting domain death agonist
- BID isoform ES(1b)
- BID isoform L(2)
- BID isoform Si6
- BID
- desmocollin type 4
- FP497
- Human BID coding sequence
- MGC15319
- MGC42355
- p22 BID
Background
Bid, a BH3 domain containing proapoptotic Bcl2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase 8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and releases its potent proapoptotic activity, which in turn induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In animal model studies, Bid deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas.
