BRCA1 Antibody (9F12) Summary
| Immunogen |
BRCA1 protein fragment expressed in E. coli corresponding to amino acids 341-748.
|
| Localization |
Nuclear
|
| Specificity |
This antibody will recognize human BRCA1.
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
BRCA1
|
| Purity |
Protein G purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
| Theoretical MW |
220 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.2)
|
| Preservative |
No Preservative
|
| Concentration |
1 mg/ml
|
| Purity |
Protein G purified
|
Alternate Names for BRCA1 Antibody (9F12)
- BRCA1
- BRCAI
- breast and ovarian cancer susceptibility protein 1
- breast and ovarian cancer sususceptibility protein
- breast cancer 1, early onset
- breast cancer type 1 susceptibility protein
- EC 6.3.2
- EC 6.3.2.-
- IRIS
- PNCA4
- PSCP
- subunit 1
Background
BRCA1-9F12 recognizes full-length BRCA1, a 220kDa nuclear phosphoprotein. In a high proportion of breast and ovarian cancer cell lines, BRCA1 aberrantly mislocates to the cytoplasm. Its usefulness to monitor functional inactivation of BRCA1 in sporadic breast cancers is under active investigation.
