Blk Antibody (9D10D1) Summary
| Immunogen |
Ni-NTA purified truncated recombinant BLK expressed in E. Coli strain BL21 (DE3)
|
| Specificity |
BLK (9D10D1)
|
| Isotype |
IgG2a
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
BLK
|
| Purity |
Unpurified
|
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|
Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Ascites
|
| Preservative |
0.03% Sodium Azide
|
| Purity |
Unpurified
|
Alternate Names for Blk Antibody (9D10D1)
- B lymphocyte kinase
- B lymphoid tyrosine kinase
- BLK nonreceptor tyrosine kinase
- Blk
- EC 2.7.10.2
- MGC10442
- MODY11
- p55-Blk
- tyrosine-protein kinase Blk
Background
BLK ( B lymphoid tyrosine kinase), with 505-amino acid protein (about 56KDa), belongs to the Src non-receptor tyrosine kinases family.Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization, and membrane trafficking.Blk is expressed exclusively by B lymphocytes and it is thought to function in a signal transductory pathway specific to this lineage. B lymphoid expression of an active Blk mutant caused proliferation of B progenitor cells and enhanced responsiveness of these cells to interleukin 7. Thus, sustained activation of Blk induces responses normally associated with the pre-BCR.
