CCR1 Antibody Summary
| Immunogen |
Synthetic peptide: TEDYDTTTEFDYGDATPC, corresponding to amino acids 7 – 24 of Human CCR1.
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| Epitope |
N-terminal extracellular domain of human CCR1.
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| Localization |
Cell Membrane
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| Specificity |
Peptide sequence is < 50 % identical to other chemokine receptors in this region.
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
CCR1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
ELISA, Western Blot and Immunocytochemistry: In WB predicted molecular weight is 62. 6 kDa. Optimal dilutions/concentrations should be determined by the end user.
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| Positive Control |
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Reactivity Notes
Cross-reacts with Human. Does not cross-react with Mouse. Expected to cross-react with Macaque Monkey (88% identity with immunogen) due to sequence homology. Not yet tested in other species.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS (pH 7.2) and 1.0 mg/ml BSA
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| Preservative |
Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for CCR1 Antibody
- C-C chemokine receptor type 1
- CC-CKR-1
- CCR1
- CCR-1
- CD191 antigen
- CD191
- chemokine (C-C motif) receptor 1
- CKR1
- CKR-1
- CMKBR1SCYAR1
- CMKR1
- HM145C-C CKR-1
- LD78 receptor
- Macrophage inflammatory protein 1-alpha receptor
- MIP-1alpha-R
- MIP1aR
- RANTES receptor
- RANTES-R
Background
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP3), and myeloid progenitor inhibitory factor 1 (MPIF1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.Receptors for the C-C chemokine family include CCR-1, CCR-2A, CCR-3, CCR-4, CCR-5 and the Duffy blood group antigen.The C-C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation.
