CCR5 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human CCR5. The exact sequence is proprietary.
|
| Localization |
Cell membrane
|
| Predicted Species |
Rhesus Macaque (100%), Primate (100%). Backed by our 100% Guarantee.
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
CCR5
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
41 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Expected cross reactivity based on sequence homology: Mouse (87%), Feline (83%), Canine (85%), Rabbit (82%), Rat (87%), Bovine (86%), Porcine (86%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.0) and 20% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for CCR5 Antibody
- C-C CKR-5
- C-C motif chemokine receptor 5 A159A
- CCCKR5
- CC-CKR-5FLJ78003
- CCR5
- CCR-5
- CD195 antigen
- CD195
- chemokine (C-C motif) receptor 5
- chemokine receptor CCR5
- chemr13
- CKR5
- CKR-5
- HIV-1 fusion coreceptor
- IDDM22CMKBR5C-C chemokine receptor type 5
Background
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
