CD28 ELISA Kit Summary
| Standard Curve Range |
0.78 – 50 ng/mL
|
| Sensitivity |
0.18 ng/mL
|
| Kit Type |
ELISA Kit
|
| Gene |
CD28
|
Applications/Dilutions
| Application Notes |
The human sCD28 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human sCD28.
|
Packaging, Storage & Formulations
| Storage |
Storage of components varies. See protocol for specific instructions.
|
Kit Components
| Components |
|
Alternate Names for CD28 ELISA Kit
- CD28 antigen (Tp44)
- CD28 antigen
- CD28 molecule
- CD28
- MGC138290
- T-cell-specific surface glycoprotein CD28
- Tp44
Background
CD28 is a 44 kDa, disulphide- bonded, homodimeric glycoprotein, which is constitutively expressed on the surface of the majority of T-cells. CD28 is structurally very closely related to another molecule expressed in activated T-cells, CTLA-4. Ligation of CD28 by its counter receptor, B7, expressed on the surface of antigen presenting cells, has been shown to induce signals that, in synergy with those derived from engagement of the T-cell receptor by an antigen bound to a major histocompatibilty complex, enhance proliferation and cytokine production. Manipulation of this interaction can have dramatic effects on the outcome of T-cell activation. Considerable research has been done on the CD28/B7 costimulatory pathway. Blocking thereof results in immunosuppression with implications for the treatment of autoimmune diseases, allergy, organ transplantation and graft versus host disease. Activating the CD28/B7 pathway could be useful for including the immune system to recognize and eliminate tumors that evade the immune system
