CD2 Antibody (I/35A) Summary
| Immunogen |
Sheep T cell blasts
|
| Specificity |
NB100-65316 recognizes ovine CD2, a 55kD cell surface antigen. Ovine CD2 is expressed by peripheral T cells expressing CD4 or CD8, but not by the CD4/CD8 negative subset, which comprises approximately 20% of cells in peripheral blood. In the thymus most cells express low levels of CD2. In immunohistochemical studies tissue macrophages in lymph nodes are found to be CD2 +ve. NB100-65316 blocks sheep autologous E rosetting.
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
CD2
|
| Purity |
Protein G purified
|
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|
Applications/Dilutions
| Dilutions |
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Reactivity Notes
Reacts with Sheep. Cross reacts with Goat.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
No buffer
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein G purified
|
Alternate Names for CD2 Antibody (I/35A)
- CD2 antigen (p50), sheep red blood cell receptor
- CD2 antigen
- CD2 molecule
- CD2
- Erythrocyte receptor
- FLJ46032
- LFA-2
- LFA-3 receptor
- lymphocyte-function antigen-2
- Rosette receptor
- SRBC
- T11
- T-cell surface antigen CD2
- T-cell surface antigen T11/Leu-5
Background
CD2 is a surface antigen of the human T lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. CD2 interacts with lymphocyte function associated antigen (LFA3) and CD48/BCM1 to mediate adhesion between T cells and other cell types. CD2 is implicated in the triggering of T cells, the cytoplasmic domain is implicated in the signaling function. It is useful for the identification of lymphomas and leukemias of T cell origin.
