CDX2 Antibody Summary
| Immunogen |
Peptide with sequence EQLSPGGQRRNLCE corresponding to internal region according to NP_001256.1.
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| Specificity |
No cross-reactivity expected with CDX1 and 4
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
CDX2
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Approx. 38 kDa band observed in human kidney and liver lysates is reported in scientific literature (PMID: 12117877).
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| Positive Control |
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Mouse, Rat, Canine.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
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| Preservative |
0.02% Sodium Azide
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| Concentration |
0.5 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for CDX2 Antibody
- caudal type homeo box transcription factor 2
- caudal type homeobox 2
- Caudal-type homeobox protein 2
- CDX2
- CDX3
- CDX-3
- CDX3caudal type homeobox transcription factor 2
- homeobox protein CDX-2
Background
CDX2 is a caudal type homeobox gene that encodes an intestine-specific transcription factor that is expressed early in intestinal development and may be involved in the regulation of proliferation and differentiation of intestinal epithelial cells. It is expressed in the nuclei of epithelial cells throughout the intestine, from duodenum to rectum. The CDX2 protein is expressed in primary and metastatic colorectal carcinomas and has also been demonstrated in the intestinal metaplasia of the stomach and intestinal-type gastric cancer, while it is not expressed in the normal gastric mucosa. Studies have shown that CDX2 is superior marker compared to CK20.
