Dkk-1 Antibody Summary
| Immunogen |
Synthetic peptide surrounding amino acid 255 of mouse Dkk1.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
DKK1
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Western blotting (0.5-4 ug/ml). However, the optimal conditions should be determined individually. The antibody detects ~35 kDa Dkk1 of human, mouse and rat origins.
|
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.2), 0.5% BSA and 30% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
0.5 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Dkk-1 Antibody
- dickkopf (Xenopus laevis) homolog 1
- dickkopf homolog 1 (Xenopus laevis)
- dickkopf related protein-1
- Dickkopf-1
- dickkopf-related protein 1
- Dkk1
- Dkk-1
- hDkk-1
- SKdickkopf-1 like
Background
DKK1 is a secreted factor that has been linked to the function of osteoblasts. Elevated DKK1 levels in bone marrow plasma and peripheral blood from patients with multiple myeloma correlated with the gene-expression patterns of DKK1 and were associated with the presence of focal bone lesions. The production of DKK1, an inhibitor of osteoblast differentiation, by myeloma cells is associated with the presence of lytic bone lesions in patients with multiple myeloma.
