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Product: Guanidine (hydrochloride)

EIF2B2 Antibody Summary

Immunogen
EIF2B2 (NP_055054.1, 1 a.a. – 351 a.a.) full-length human protein. MPGSAAKGSELSERIESFVETLKRGGGPRSSEEMARETLGLLRQIITDHRWSNAGELMELIRREGRRMTAAQPSETTVGNMVRRVLKIIREEYGRLHGRSDESDQQESLHKLLTSGGLNEDFSFHYAQLQSNIIEAINELLVELEGTMENIAAQALEHIHSNEVIMTIGFSRTVEAFLKEAARKRKFHVIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGALRAVTGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHKFVAPEEVLPFTEGDILEKVSVHCPVFDYVPPELITLFISNIGGNAPSYIYRLMSELYHPDDHVL
Specificity
EIF2B2 – eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa,
Clonality
Polyclonal
Host
Rabbit
Gene
EIF2B2
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Western Blot
Application Notes
Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB and also on transfected lysate in WB. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
Protein A purified

Notes

Quality control test: Antibody reactive against mammalian transfected lysate.

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for EIF2B2 Antibody

  • eIF-2B GDP-GTP exchange factor subunit beta
  • EIF2B
  • EIF2BB
  • EIF-2Bbeta
  • eukaryotic translation initiation factor 2B, subunit 2 (beta, 39kD)
  • eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
  • S20I15
  • S20III15
  • translation initiation factor eIF-2B subunit beta

Background

Eukaryotic initiation factor-2B (EIF2B) is a GTP exchange protein essential for protein synthesis. It consists of alpha (EIF2B1; MIM 606686), beta (EIF2B2), gamma (EIF2B3; MIM 606273), delta (EIF2B4; MIM 606687), and epsilon (EIF2B5; MIM 603945) subunits. EIF2B activates its EIF2 (see MIM 603907) substrate by exchanging EIF2-bound GDP for GTP.[supplied by OMIM]

PMID: 11743947

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Author: premierroofingandsidinginc

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Product: Neostigmine (methyl sulfate)

EIF2B2 Antibody Summary

Immunogen
The immunogen for this antibody was a sequence from 1a.a. to 210a.a. from EIF2B2(a 351a.a. long protein)
Specificity
EIF2B2
Clonality
Polyclonal
Host
Chicken
Gene
EIF2B2
Purity
Immunogen affinity purified
Innovators Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Learn about the Innovators Reward

Applications/Dilutions

Dilutions
  • Western Blot
  • ELISA
Application Notes
ELISA: Direct Elisa Test. Protein as test antigen. Affi-pure IgY as primary antibody and Goat anti-IgY HRP as 2nd antibody. Fixed amount of antibody (1 ug/ml) and serial dilutions of antigen.

Reactivity Notes

This antibody is reactive against Human, mouse.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
No Preservative
Purity
Immunogen affinity purified

Alternate Names for EIF2B2 Antibody

  • eIF-2B GDP-GTP exchange factor subunit beta
  • EIF2B
  • EIF2BB
  • EIF-2Bbeta
  • eukaryotic translation initiation factor 2B, subunit 2 (beta, 39kD)
  • eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
  • S20I15
  • S20III15
  • translation initiation factor eIF-2B subunit beta

Background

Eukaryotic initiation factor 2B (EIF2B) is a GTP exchange protein essential for protein synthesis. It consists of alpha, beta, gamma, delta and epsilon subunits. EIF2B activates its EIF2 substrate by exchanging EIF2 bound GDP for GTP.Defects in EIF2B2 are a cause of leukoencephalopathy with vanishing white matter (VWM). VWM is a brain disease that occurs mainly in children. The neurological signs of VWM include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. Head trauma leads only to motor deterioration whereas infections with fever may end in coma. Death occurs after a variable period of a few years to a few decades, usually following an episode of fever and coma.Defects in EIF2B2 are a cause of ovarioleukodystrophy; also known as vanishing white matter leukodystrophy with ovarian failure. It is a condition of ovarian failure associated with cerebral abnormalities similar to those in patients with vanishing white matter leukodystrophy.

PMID: 21531714

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Author: premierroofingandsidinginc