Product: Antazoline (hydrochloride)
ER alpha/NR3A1 Antibody Summary
| Immunogen |
Synthetic peptide (Human) (C terminal).
|
| Localization |
Nuclear
|
| Specificity |
This Ab strongly stains the nucleus epithelial cells of breast carcinomas.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
ESR1
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
This product is useful for Immunohistochemistry Paraffin. If a 6mL or 7mL pre-diluted size is purchased this product can be used Neat (without further dilution). Use recommended dilution for the concentrated vials only.
|
Reactivity Notes
Cross-reacts with Human, Mouse and Rat.Not yet tested in other species.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Prediluted antibody with 10mM PBS (pH 7.4) and BSA
|
| Preservative |
0.1% Sodium Azide
|
| Purity |
Immunogen affinity purified
|
Alternate Names for ER alpha/NR3A1 Antibody
- ER alpha
- ER
- Era
- ER-alpha
- ESR1
- ESRESRA
- Estradiol receptor
- estrogen receptor 1
- estrogen receptor alpha delta 3*4,56,7*/819-2 isoform
- estrogen receptor alpha delta 4 +49 isoform
- estrogen receptor alpha delta 4*5,6,7*/654 isoform
- estrogen receptor alpha
- estrogen receptor
- NR3A1
- NR3A1DKFZp686N23123
- Nuclear receptor subfamily 3 group A member 1
Background
Estrogen Receptor alpha is a 65 kDa protein and a member of the steroid family of nuclear receptors. Estrogen Receptor alpha is a ligand-activated transcription factor that, when bound to estrogen, induces a conformational change that allows dimerization and binding to estrogen response element sequences. When bound to DNA, Estrogen Receptor alpha can positively or negatively regulate gene transcription. Like other steroid hormone receptors, Estrogen Receptors are intracellular proteins. Estrogen Receptors play an important role in regulating mammary gland growth and differentiation. Breast tumors that are ER positive may also show a more favorable response to anti-estrogen therapies
