Enolase 2/Neuron-specific Enolase Antibody (5E2) Summary
| Immunogen |
Purified full length native protein (Human).
|
| Localization |
Cytoplasmic
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| Marker |
Neuronal Marker
|
| Specificity |
NSE (5E2)
|
| Isotype |
IgG2a
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
ENO2
|
| Purity |
Protein G purified
|
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|
Applications/Dilutions
| Dilutions |
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| Application Notes |
Recommended pairs for sandwich immunoassay (coating – conjugate): NB200-421 – NB200-422, NB200-422 – NB200-421.
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| Positive Control |
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Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
0.09% Sodium Azide
|
| Purity |
Protein G purified
|
Alternate Names for Enolase 2/Neuron-specific Enolase Antibody (5E2)
- 2-phospho-D-glycerate hydrolyase
- 2-phospho-D-glycerate hydro-lyase
- EC 4.2.1.11
- ENO2
- enolase 2 (gamma, neuronal)
- Enolase 2
- gamma-Enolase
- Neural enolase
- neuron specific gamma enolase
- neurone-specific enolase
- Neuronspecific Enolase
- Neuron-specific enolase
- NSE
Background
Enolase is a glycolytic enzyme catalyzing the reaction pathway between 2 phospho glycerate and phosphoenol pyruvate. In mammals, enolase molecules are dimers composed of three distinct subunits (alpha, beta and gamma). The alpha subunit is expressed in most tissues and the beta subunit only in muscle. The gamma subunit is expressed primarily in neurons, in normal and in neoplastic neuroendocrine cells. NSE (neuron specific enolase) is found in elevated concentrations in plasma and certain neoplasias. These include pediatric neuroblastoma and small cell lung cancer. Coexpression of NSE and chromogranin A is common in neuroendocrine neoplasms.
