Product: Lurasidone Metabolite 14283 D10
FPR1 Antibody Summary
| Immunogen |
Synthetic 16 amino acid peptide from 3rd extracellular domain of human FPR1.
|
| Localization |
Cell Membrane
|
| Specificity |
Human FPR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
FPR1
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Predicted cross-reactivity based on sequence identity: Chimpanzee (100%), Gorilla (94%), Orangutan (88%).
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.1% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for FPR1 Antibody
- fMet-Leu-Phe receptor
- fMLF-R
- fMLP receptor
- FMLP
- formyl peptide receptor 1
- FPR1
- FPRfMet-Leu-Phe receptor
- N-formyl peptide receptor
- N-formylpeptide chemoattractant receptor
Background
Formyl peptide receptor 1, a Chemoattractant Receptor, mediates chemotaxis, degranulation, and superoxide production, as part of the inflammatory response. Bacterial N-formylmethionyl peptides and Annexin A1, specific ligands for FPR1, attract polymorphonuclear neutrophils to sites of infection. FPR receptors promote the phosphorylation and downregulation of CCR5, which has been shown to inhibit HIV infection. Therefore, ligands for an FPR receptor may be able to inhibit HIV infection. (WO0157074) FPR1 has been reported in blood monocytes, neutrophils, and phagocytes, as well as in liver, astrocytes, and microglia. ESTs have been isolated from B-cell/lung/testis, blood, brain, eye, heart, liver/spleen, kidney, lung, pancreas, placenta, spleen, and uterus libraries.
