Product: Benzetimide (hydrochloride)
Fibrinopeptide A Antibody (49D2) Summary
| Immunogen |
fibrinopeptide A conjugated with a carrier protein.
|
| Specificity |
Fibrinopeptide A region in the alpha-chain of fibrinogen and free fibrinopeptide A.
|
| Isotype |
IgG2a
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
FGA
|
| Purity |
Protein A purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Recommended pairs for sandwich immunoassay (capture-detection): NB100-73043 – NB120-10068
|
Reactivity Notes
Human.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
0.09% Sodium Azide
|
| Purity |
Protein A purified
|
Alternate Names for Fibrinopeptide A Antibody (49D2)
- Fib2
- fibrinogen alpha chain
- fibrinogen, A alpha polypeptide
- MGC119422
- MGC119423
- MGC119425
Background
Fibrinogen is the main protein of the blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A and B are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerisation forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases.
