GFAP Antibody (6F2) Summary
| Immunogen |
Glial fibrillary acidic protein from human brain.
|
| Localization |
Cytoplasm
|
| Marker |
Astrocyte Marker
|
| Specificity |
This antibody is specific to a 52 kD intermediate filament protein in brain and spinal cord. It stains astrocytes and CNS ependymal cells but does not stain oligodendrocytes or neurons. This antibody does not cross react with any other intermediate filament proteins. However, it cross reacts with GFAP from mouse and rabbit.
|
| Isotype |
IgG1 Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
GFAP
|
| Purity |
Tissue culture supernatant
|
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|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Human and Rabbit.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
No buffer
|
| Preservative |
Sodium Azide
|
| Purity |
Tissue culture supernatant
|
Alternate Names for GFAP Antibody (6F2)
- FLJ45472
- GFAP astrocytes
- GFAP
- glial fibrillary acidic protein
Background
Glial fibrillary acidic protein (GFAP) is a member of the class III intermediate filament protein family. It is heavily, and specifically, expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non myelinating Schwann cells in peripheral nerves. In addition, neural stem cells frequently strongly express GFAP. Antibodies to GFAP are therefore very useful as markers of astrocytic cells. In addition many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes.
