GRP78/HSPA5 Antibody (4E3) Summary
| Immunogen |
Purified recombinant fragment of human HSPA5 expressed in E. Coli.
|
| Marker |
ER Stress Marker
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
HSPA5
|
| Purity |
Unpurified
|
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|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Human
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Ascites
|
| Preservative |
0.03% Sodium Azide
|
| Purity |
Unpurified
|
Alternate Names for GRP78/HSPA5 Antibody (4E3)
- 78 kDa glucose-regulated protein
- BIP
- Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78
- FLJ26106
- GRP78
- GRP-78
- GRP78BIP
- Heat shock 70 kDa protein 5
- heat shock 70kD protein 5 (glucose-regulated protein, 78kD)
- heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
- HSP70-5
- HSPA5
- Immunoglobulin heavy chain-binding protein
- MIF2
Background
Binding immunoglobulin protein (BiP) belongs to the family of ~70 kDa heat shock proteins (HSP 70). It is a stress response protein which is induced by agents or conditions that adversely affect endoplasmic reticulum (ER) function. This protein is essential for the proper glycosylation, folding as well as for the maintenance of cell homeostasis and the prevention of apoptosis. Recombinant human BIP protein, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
