Product: PF-2545920 (hydrochloride)
Grancalcin Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human Grancalcin. The exact sequence is proprietary.
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| Localization |
Cytoplasm; Membrane
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| Predicted Species |
Rhesus Macaque (93%). Backed by our 100% Guarantee.
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| Isotype |
IgG
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
GCA
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| Purity |
Immunogen affinity purified
|
| Innovators Reward |
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|
Applications/Dilutions
| Dilutions |
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| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
24 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Mouse (88%), Rat (87%), Xenopus laevis (81%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 20% Glycerol
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| Preservative |
0.01% Thimerosal
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| Concentration |
0.99 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Grancalcin Antibody
- EF-hand calcium-binding protein
- grancalcin, EF-hand calcium binding protein
- grancalcin, penta-EF-hand protein
Background
This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation. [provided by RefSeq]
