Product: Prim-O-glucosylcimifugin
HLA-DR Antibody (YD1/63.4.10) Summary
| Immunogen |
DAUDI cells
|
| Specificity |
Recognises a monomorphic determinant of the human HLA-DR antigen (MHC Class II) expressed by B lymphocytes, activated T cells by monocytes. This product is routinely tested in flow cytometry on human peripheral blood lymphocytes.
|
| Isotype |
IgG2a
|
| Clonality |
Monoclonal
|
| Host |
Rat
|
| Gene |
HLA-DRA
|
| Purity |
Protein G purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
The epitope recognised by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. The use of acetone fixation for frozen sections is recommended.
|
Reactivity Notes
Reacts with Human. Does not react with Rat.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Phosphate buffered saline
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein G purified
|
Alternate Names for HLA-DR Antibody (YD1/63.4.10)
- FLJ51114
- histocompatibility antigen HLA-DR alpha
- HLA class II histocompatibility antigen, DR alpha chain
- HLADR
- HLA-DR
- HLA-DRA
- HLA-DRA1
- major histocompatibility complex, class II, DR alpha
- MHC cell surface glycoprotein
- MHC class II antigen DRA
- MHC Class II DR
- MLRW
Background
HLA DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of an alpha chain (36 kDa) and a beta chain (27 kDa). It is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T helper cells. They therefore have a critical role in the initiation of the immune response.
