IFN-gamma Antibody (3F1E3) Summary
| Immunogen |
Ni-NTA purified recombinant human IFN-gamma expressed in E. Coli strain BL21 (DE3)
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| Specificity |
IFN-gamma (3F1E3)
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| Isotype |
IgG1
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
IFNG
|
| Purity |
Protein A or G purified
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Western Blot and ELISA ELISA: Determining optimal working dilutions by titration test.
|
| Theoretical MW |
19.3 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
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| Preservative |
0.03% Sodium Azide
|
| Purity |
Protein A or G purified
|
Alternate Names for IFN-gamma Antibody (3F1E3)
- IFG
- IFI
- IFNG
- IFNgamma
- IFN-gamma
- Immune interferon
- interferon gamma
- interferon, gamma
Background
Interferon-gamma (IFN-gamma) is a pro-inflammatory cytokine that is central in host resistance to infection. It is mainly produced by natural killer cells and CD4+ and CD8+ T cells, its receptors are found on nearly all cells, where it activates diverse responses that enable potential host cells to prevent invasive infection by bacteria, parasites and viruses. Takayanagi et al. (2000) demonstrated that IFN-gamma strongly suppresses osteoclastogenesis by interfering with the RANKL (602642)-RANK (603499) signaling pathway. Tsubota et al. (1999) reported that this upregulation in Sjogren syndrome patients may be controlled by interferon-gamma through the activation of transcription factor NFKB
