IL-12 R beta 1 Antibody Summary
| Immunogen |
Peptide with sequence C-HVSVKNHSLDSVS corresponding to internal region according to NP_005526.1.
|
| Epitope |
HVSVKNHSLDSVS – Internal region
|
| Specificity |
This antibody is expected to recognize isoform 1 (NP_005526.1) only.
|
| Clonality |
Polyclonal
|
| Host |
Goat
|
| Gene |
IL12RB1
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
|
| Application Notes |
WB: Approx. 100 kDa band observed in human peripheral blood mononucleocytes lysates (calculated MW of 73.1 kDa band according to NP_005526.1). The observed molecular weight corresponds to the glycosylated form.
|
|
| Publications |
|
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
0.5 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for IL-12 R beta 1 Antibody
- CD212 antigen
- CD212
- IL-12 R beta 1
- IL-12 receptor beta component
- IL-12 receptor subunit beta-1
- IL12R beta 1
- IL-12R subunit beta-1
- IL12R
- IL12RB
- IL12RB1
- IL-12Rb1
- IL-12R-BETA1
- IL-12R-beta-1
- interleukin 12 receptor, beta 1
- interleukin-12 receptor beta-1 chain
- interleukin-12 receptor subunit beta-1
- MGC34454
Background
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
