IL-20 R beta/FNDC6 Antibody (20RNTC) Summary
| Immunogen |
The immunogen for this antibody is FNDC6 (IL-20R2).
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| Isotype |
IgG2a Kappa
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| Clonality |
Monoclonal
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| Host |
Rat
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| Gene |
IL20RB
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| Purity |
Protein A or G purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This 20RNTC antibody has been tested by immunofluorescent staining and flow cytometric analysis of fixed and permeabilized A375 cells. This 20RNTC antibody has also been reported for use in immunocytochemistry and immunoblotting.
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Reactivity Notes
Human, Mouse
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
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| Buffer |
Aqueous, may contain carrier protein/stabilizer.
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| Preservative |
0.09% Sodium Azide
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| Concentration |
0.5 mg/ml
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| Purity |
Protein A or G purified
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Alternate Names for IL-20 R beta/FNDC6 Antibody (20RNTC)
- FNDC6
- DIRS1
- FNDC6
- IL-20 R beta
- IL20R beta
- IL-20R2
- IL20RB interleukin 20 receptor beta
- IL20RB
- IL-20Rb
- MGC34923
Background
This 20RNTC monoclonal antibody recognizes mouse and human IL-20R2 (interleukin-20 receptor 2, IL-20Rb) in either of its two heterodimeric complexes formed by pairing with IL-20R1 or IL-22R1. IL-20R2 belongs to the class II cytokine receptor family that shares a characteristic pattern of cysteine, proline and tryptophan residues in the extracellular domain. IL-20R2 paired with IL-20R1 forms a receptor that binds IL-20, IL-19, or IL-24. IL-20R2 paired with IL22R1 forms a receptor that binds IL-20 or IL-24. The IL-20R complex signals primarily via the JAK-STAT pathway. IL-20R2 is found predominantly on cells of epithelial origin such as gut and skin and can be upregulated during inflammation. Immunofluorescent staining of A375 cells reveals a punctate staining pattern at the cell membrane, as well as diffuse, cytoplasmic staining that is likely associated with protein synthesis and transport in the endoplasmic reticulum and golgi.
