ITCH/AIP4 Antibody Summary
| Immunogen |
The immunogen recognized by this antibody maps to a region between residue 650 to 700 of human itchy homolog E3 ubiquitin protein ligase using the numbering given in entry AAH11571.1 (GeneID 83737).
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
ITCH
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
|
| Application Notes |
This antibody is useful for western blot. It is not recommended for immunoprecipitation.
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Reactivity Notes
Human
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
TBS and 0.1% BSA
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
0.2 mg/ml
|
| Purity |
Immunogen affinity purified
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Alternate Names for ITCH/AIP4 Antibody
- AIF4
- AIP4
- AIP4dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4))
- atrophin-1 interacting protein 4
- Atrophin-1-interacting protein 4
- dJ468O1.1
- EC 6.3.2
- EC 6.3.2.-
- ITCH
- itchy (mouse homolog) E3 ubiquitin protein ligase
- itchy E3 ubiquitin protein ligase homolog (mouse)
- itchy homolog E3 ubiquitin protein ligase
- NAPP1
- NAPP1E3 ubiquitin-protein ligase Itchy homolog
- NFE2-associated polypeptide 1
- ubiquitin protein ligase ITCH
Background
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells. [provided by RefSeq]
