Product: Acetylene-linker-Val-Cit-PABC-MMAE
IgE Antibody (4F4) Summary
| Immunogen |
IgE from myelomatous human serum.
|
| Specificity |
IgE Ce3-domain specific.
|
| Isotype |
IgG2a
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
IGHE
|
| Purity |
Protein A purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Detection of total IgE level and IgE antibodies in ELISA.Recommended pairs for Coating -Conjugate: NB110-8331 – NB110-8330. NB110-8330 can be used for IgE purification by affinity chromatography.
|
Reactivity Notes
Cross-reacts with Human.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
0.09% Sodium Azide
|
| Purity |
Protein A purified
|
Alternate Names for IgE Antibody (4F4)
- IgE
- immunoglobulin heavy constant epsilon
Background
IgE is typically the least abundant isotype – blood serum IgE levels in a normal (“non-atopic”) individual are approx. 150 ng/ml, compared to 10 mg/ml for the IgGs – it is capable of triggering the most powerful immune reactions. Most of our knowledge of IgE has come from research into the mechanism of a form of allergy known as type 1 hypersensitivity. There is much speculation into what physiological benefits IgE contributes, and so far, circumstantial evidence in animal models and statistical population trends have hinted that IgE may be beneficial in fighting gut parasites such as Schistosoma mansoni, but this has not been conclusively proven in humans. IgE may play an important role in the immune systems recognition of cancer, in which the stimulation of a strong cytotoxic response against cells displaying only small amounts of early cancer markers would be beneficial. IgE may be an important target in treatments for allergy and asthma.
