Integrin alpha 3/CD49c Antibody Summary
| Immunogen |
The immunogen for this antibody was a sequence from 1015a.a. to 1051a.a. from Integrin alpha-3(a 1051a.a. long protein)
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| Localization |
Membrane; single-pass type I membrane protein.
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| Specificity |
Integrin alpha 3
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| Clonality |
Polyclonal
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| Host |
Chicken
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| Gene |
ITGA3
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000. Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development.
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| Positive Control |
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Reactivity Notes
This antibody is reactive against Human, rat.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
No Preservative
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| Purity |
Immunogen affinity purified
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Alternate Names for Integrin alpha 3/CD49c Antibody
- antigen identified by monoclonal J143
- CD49 antigen-like family member C
- CD49c antigen
- CD49c
- FLJ34631
- FLJ34704
- FRP-2
- Galactoprotein B3
- GAP-B3
- GAPB3CD49C
- Integrin alpha 3
- integrin alpha-3
- integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
- ITGA3
- MSK18
- VCA-2
- very late activation protein 3 receptor, alpha-3 subunit
- VL3A
- VLA-3 subunit alpha
- VLA3a
Background
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular-matrix proteins. The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 (VLA3), very common antigen 2 (VCA2), extracellular matrix receptor 1 (ECMR1), and galactoprotein b3 (GAPB3).Integrin alpha-3/beta-1 is a receptor for fibronectin. laminin. collagen. epiligrin. thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
