Integrin beta 2/CD18 Antibody (PNK-I) Summary
| Immunogen |
Porcine large granular lymphocytes.
|
| Specificity |
NB100-65882 recognizes the porcine homologue of human Integrin beta 2/CD18. Clone PNK-I immunoprecipitates molecules of 166, 155 and 95 kDa under reducing and non-reducing conditions. Clone PNK-I has been reported to inhibit porcine NK activity without affecting antibody-dependent cellular cytoxicity.
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
ITGB2
|
| Purity |
Protein G purified
|
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|
Applications/Dilutions
| Dilutions |
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Reactivity Notes
Cross reacts with Camel.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
No buffer
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein G purified
|
Alternate Names for Integrin beta 2/CD18 Antibody (PNK-I)
- 959 beta subunit precursor)10
- CD18 antigen
- CD18
- CD18beta 2
- cell surface adhesion glycoprotein (LFA-1
- CR3
- Integrin beta 2
- integrin beta-2
- integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1;macrophage antigen 1 (mac-1) beta subunit)
- integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
- ITGB2
- LAD
- LCAMB
- leukocyte cell adhesion molecule CD18
- leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
- LFA-1 beta
- LFA-1
- MAC-1 beta
- MF17
- MFI7
- P150
- p150,95 beta
Background
CD18 is an integrin. Integrins are integral cell surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA1, and combines with the alpha M chain to form the integrin Mac1. Integrins are known to participate in cell adhesion as well as cell surface mediated signalling. CD18 is expressed by most leucocytes. Defects in the CD18 gene result in leukocyte adhesion deficiency.
