Product: Pyrrolidinedithiocarbamate (ammonium)
Intersectin 1 Antibody Summary
| Immunogen |
The immunogen for this product maps to a region between residue 850 and 900 of human Intersectin 1 using the numbering given in entry NP_003015.2 (GeneID 6453).
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| Predicted Species |
Primate (100%), Ferret (100%), Monkey (100%), Squirrel (100%), Canine (100%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
ITSN1
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| Purity |
Immunogen affinity purified
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| Innovators Reward |
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Based on 100% sequence identity, this antibody is predicted to react with Rhesus Monkey, Gorilla, Chimpanzee, Nine-banded armadillo, White-tufted-ear marmoset, Dusky titi monkey, Crab-eatiing macaque, Olive baboon, European domestic ferret, Small-eared galago and Thirteen-lined ground squirrel.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
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| Buffer |
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
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| Preservative |
0.09% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for Intersectin 1 Antibody
- 11
- intersectin 1 (SH3 domain protein)
- intersectin short variant 12
- intersectin-1
- ITSN
- SH3 domain protein-1A
- SH3 domain-containing protein 1A
- Src homology 3 domain-containing protein
Background
Intersectin 1 is an adapter protein that may provide an indirect link between the endocytic membrane traffic and the actin assembly machinery. It may regulate the formation of clathrin-coated vesicles. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Intersectin 1 is overexpressed in brain from Down syndrome foetuses suggesting a gene dosage-dependent contribution to the abnormalities of Down syndrome. Intersectin 1 interacts with dynamin, CDC42, SNAP25 and SNAP23. It clusters several dynamin in a manner that is regulated by alternative splicing. Intersectin 1 also binds clathrin-associated proteins and other components of the endocytic machinery, such as SPIN90, EPS15, EPN1, EPN2 and STN2. Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Isoform 1 could be involved in brain-specific synaptic vesicle recycling.
