KLC1 Antibody Summary
| Immunogen |
The immunogen for this product maps to a region between residue 150 and 200 of human kinesin light chain 1 using the numbering given in entry NP_891553.2 (GeneID 3831).
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
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| Gene |
KLC1
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Human
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for KLC1 Antibody
- hKLC1B
- hKLC1G
- hKLC1J
- hKLC1S
- kinesin 2 60/70kDa
- kinesin 2
- kinesin light chain 1
- KLC 1
- KLChKLC1N
- KNS2AhKLC1P
- KNS2hKLC1R
- medulloblastoma antigen MU-MB-2.50
- MGC15245
Background
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named “kinesin 2”, this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq]
