LAIR1 Antibody Summary
| Immunogen |
internal region
|
| Epitope |
C-NDTEDVSQASPSE
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| Specificity |
This antibody is expected to recognize both isoforms (NP_002278.1; NP_068352.1).
|
| Clonality |
Polyclonal
|
| Host |
Goat
|
| Gene |
LAIR1
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
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|
| Application Notes |
This antibody works in ELISA and Western Blot. Approx 28kDa band observed in Human Lymph Node lysates (calculated MW of 29.8kDa according to NP_068352.1). Recommended concentration: 1-3ug/ml.
|
|
| Publications |
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Reactivity Notes
Cross reacts with Human.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
|
| Preservative |
0.02% Sodium Azide
|
| Purity |
Immunogen affinity purified
|
Alternate Names for LAIR1 Antibody
- CD305 antigen
- CD305
- CD305leukocyte-associated Ig-like receptor 1
- hLAIR1
- LAIR1
- LAIR-1
- leukocyte-associated immunoglobulin-like receptor 1
Background
CD305 or Leukocyte-associated Ig-like receptor-1 (LAIR-1) is a 46 kD cell surface molecule that functions as an inhibitory collagen-receptor on the majority of cells of the immune system. The mouse LAIR-1 molecule is expressed primarily on monocytes/macrophages and also on T cells, NK cells and dendritic cells. Unlike human B cells, mouse B cells do not express LAIR-1. The cytoplasmic tail of mouse LAIR-1 can be phosphorylated leading to the recruitment of SH2-containing tyrosine phosphatase(SHP)-2 and C-terminal Src kinase.
