Product: Propafenone (D9 hydrochloride)
Leukotriene B4 R1 Antibody Summary
| Immunogen |
Synthetic 16 amino acid peptide from C-terminus of human Leukotriene B4 Receptor.
|
| Localization |
Integral membrane protein.
|
| Specificity |
Human Leukotriene B4 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
LTB4R
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (88%), Mouse (88%), Rat (88%), Equine (88%), Opossum (88%).
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.1% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Leukotriene B4 R1 Antibody
- BLT1
- chemokine receptor-like 1
- CMKRL1
- Leukotriene B4 R1
- leukotriene B4 receptor
- Leukotriene B4R1
- LTB4R
- LTB4R1
- LTBR1
- P2Y purinoceptor 7
- purinergic receptor P2Y, G-protein coupled, 7
Background
BLT1 is a Chemoattractant Receptor that binds the potent chemoattractant leukotriene B4 (LTB4) which is involved in defense against infection. Leukotriene B4 also activates the transcription factor PPAR alpha, resulting in the activation of genes that terminate inflammatory processes (Yokomizo et al., 1997). Although BLT1 shows homology to other P2Y receptors, it does not function as a purinoreceptor (Yokomizo et al., 1997). Part of the coding regions of BLTR2 have been duplicated and are part of the 5 UTR noncoding regions of the clusters BLT1 and CIDE-B on chromosome 14. BLT1 has been reported in blood, bone marrow, brain, heart, liver, and skeletal muscle. In addition, BLT1 has been shown to be highly expressed in leukocytes and lymphoid tissues such as spleen, thymus, and lymph node. ESTs have been isolated from B-cell/lung/testis, breast, colon, eye, kidney, skin, spleen, testis, and tonsil libraries.
