MHC Class II antigen I A beta 1 Antibody (P7/7) Summary
| Immunogen |
Cells from R8 strain rat
|
| Specificity |
NB100-64960 recognizes the rat RT1Bu/Du MHC class II antigen and is cross reactive with haplotypes c, d, l, and n. The antibody positively stains MHC class II molecules in rat strains including PVG, F334, LEW, and BN. Clone P7/7 also recognizes mouse MHC Class II, binding to a monomorphic epitope expressed by all mouse strains.
|
| Isotype |
IgG2b
|
| Clonality |
Monoclonal
|
| Host |
Rat
|
| Gene |
HLA-DRB1
|
| Purity |
Tissue culture supernatant
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Reacts with Rat. Cross reacts with Mouse.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
No buffer
|
| Preservative |
0.1% Sodium Azide
|
| Purity |
Tissue culture supernatant
|
Alternate Names for MHC Class II antigen I A beta 1 Antibody (P7/7)
- Clone P2-beta-3
- DR1
- DR-1
- DR12
- DR-12
- DR13
- DR-13
- DR14
- DR-14
- DR16
- DR-16
- DR4
- DR-4
- DR5
- DR-5
- DR7
- DR-7
- DR8
- DR-8
- DR9
- DR-9
- DRB1
- DRw10
- DRw11
- DRw8
- DW2.2/DR2.2
- FLJ75017
- FLJ76359
- HLA class II antigen beta chain
- HLA class II histocompatibility antigen, DR-1 beta chain
- HLA-DR1B
- HLA-DRB
- HLA-DRB1*
- HLA-DRB2
- HLA-DR-beta 1
- human leucocyte antigen DRB1
- leucocyte antigen DR beta 1 chain
- leucocyte antigen DRB1
- lymphocyte antigen DRB1
- major histocompatibility complex, class II, DR beta 1
- MHC class II antigen DRB1*1
- MHC class II antigen DRB1*10
- MHC class II antigen DRB1*11
- MHC class II antigen DRB1*12
- MHC class II antigen DRB1*13
- MHC class II antigen DRB1*14
- MHC class II antigen DRB1*15
- MHC class II antigen DRB1*16
- MHC class II antigen DRB1*3
- MHC class II antigen DRB1*4
- MHC class II antigen DRB1*7
- MHC class II antigen DRB1*8
- MHC class II antigen DRB1*9
- MHC class II antigen HLA-DR13
- MHC class II HLA-DR beta 1 chain
- MHC class II HLA-DR-beta cell surface glycoprotein
- MHC class II HLA-DRw10-beta
- SS1
Background
MHC Class II antigens are heterodimers consisting of one alpha chain(31-34kD) and one beta chain (26-29kD). The family of monoclonal antibodies (ER-TR 3, ER-TR 2, ER-TR 1) detect MHC class II antigens encoded by the murine Ia region of the H-2 complex, corresponding to the human HLA-DR region. MHC Class II antigens are a valuable tool for studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells, macrophages) and offer new possibilities for studying the development of T helper cells since these antibodies also stain stromal cells in the thymus. MHC Class II antigens are also inducible on a number of other cells (endothelium and epithelial cells) by interferon gamma.
