Product: Proadifen (hydrochloride)
MSH2 Antibody Summary
| Immunogen |
The immunogen recognized by this antibody maps to a region between residues 1 and 50 of human mutS homolog 2 using the numbering given in Swiss-Prot entry P43246 (GeneID 4436).
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
MSH2
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
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| Positive Control |
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| Publications |
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Reactivity Notes
Human
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
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| Buffer |
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
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| Preservative |
0.1% Sodium Azide
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| Purity |
Immunogen affinity purified
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Alternate Names for MSH2 Antibody
- COCA1
- DNA mismatch repair protein Msh2
- FCC1
- hMSH2
- HNPCC
- HNPCC1
- HNPCC1mutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1)
- LCFS2
- MSH2
- mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
- MutS protein homolog 2
Background
MSH2 is an integral component of the DNA mismatch repair (MMR) system that functions to recognize aberrant structures and signals for the repair of single base mismatches or loops in replicated DNA. MSH2 has also been demonstrated to function as an anti-recombinase and may play a role in negatively regulating DNA repair. MSH2 can heterodimerize with MSH3 or MSH6. Mutations in MSH2 are linked to hereditary nonpolyposis colon cancer (HNPCC). Alternate names for MSH2 include DNA mismatch repair protein Msh2, MutS protein homolog 2, MSH2, FCC1, COCA1, HNPCC, and HNPCC1.
