PAR4 Antibody Summary
| Immunogen |
A synthetic peptide derived from the C-terminal of human Par-4 protein. NP_003941
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| Specificity |
Prostate apoptosis response-4 (Par-4) is a 38kD protein.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
F2RL3
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| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Mouse, Rat
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
No buffer
|
| Preservative |
0.05% Sodium Azide
|
| Purity |
Immunogen affinity purified
|
Alternate Names for PAR4 Antibody
- proteinase-activated receptor 4
- coagulation factor II (thrombin) receptor-like 3
- F2RL3
- PAR4
- Protease-Activated Receptor 4
- Thrombin Receptor-like 3
Background
Par-4, originally identified as an apoptosis inducer in prostrate cancer cells, is a 332A.A WT-1 interacting protein. It consists of a C-terminal leucine zipper domain and two putative conserved NLS domains required for nuclear localization of Par-4 and induction of apoptosis. It functions as a transcriptional repressor and modulates the transcriptional activities of WT1. Expression of Par-4 is down-regulated in various cancer types. Activation of Par-4 in cancer cells results in activation of FasL-Fas-FADD-caspase8 apoptotic pathway and inhibition of NF-kB prosurvival pathway. It utilizes elevated PKA and induces selective apoptosis in cancer cells. Role of Par4 has also been associated with neuronal degradation in Alzheimers disease. Prostate apoptosis response-4 (Par-4) is a 38kD protein. It is a death domain-containing protein whose levels increase in neurons undergoing apoptosis as a result of trophic factor withdrawal or exposure to oxidative and metabolic insults. Par-4 levels are reported to be increased in lumbar spinal cord specimens from patients with amyotrophic lateral sclerosis (ALS)1 further suggesting a role in neuronal degeneration.
