PAWR / PAR4 Antibody Summary
| Immunogen |
This antibody was made against a protein fragment from the Middle Region
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| Specificity |
This product is specific for Human PAWR.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
PAWR
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| Purity |
Immunogen affinity purified
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| Innovators Reward |
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This antibody is useful in ELISA and Immunohistochemistry-Paraffin.
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| Publications |
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Reactivity Notes
Human.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
20mM Potassium Phosphate (pH 7.0) and 0.15M NaCl
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| Preservative |
No Preservative
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| Purity |
Immunogen affinity purified
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Notes
Manufactured by SDIXs proprietary Genomic Antibody Technology™. GAT FAQs. These products are available in limited quantities. Please enquire about the availability of this product before purchasing.
Alternate Names for PAWR / PAR4 Antibody
- Par-4
- PAR4prostate apoptosis response protein 4
- PRKC apoptosis WT1 regulator protein
- PRKC, apoptosis, WT1, regulator
- Prostate apoptosis response 4 protein
- prostate apoptosis response protein PAR-4
- transcriptional repressor PAR4
- WT1-interacting protein
Background
Prostate apoptosis response 4 (Par4) is a 38kD protein originally identified as the product of a gene that is upregulated in prostate tumor cells undergoing apoptosis. It is a leucine zipper and death domain containing protein whose levels increase in neurons undergoing apoptosis as a result of trophic factor withdrawal or exposure to oxidative and metabolic insults. Par4 levels are reported to be increased in their lumbar spinal cord specimens further suggesting a role in neuronal degeneration. The tumor suppressor WT1 represses and activates transcription. The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms tumor. Par4 is a WT1 interacting protein that also functions as a transcriptional repressor.
