PCNA Antibody (PC11) Summary
| Immunogen |
Protein A-PCNA fusion obtained from pC2T.
|
| Localization |
Nuclear
|
| Marker |
Proliferation Marker
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
PCNA
|
| Purity |
Protein A or G purified
|
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|
Applications/Dilutions
| Dilutions |
|
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| Positive Control |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein A or G purified
|
Alternate Names for PCNA Antibody (PC11)
- cyclin
- DNA polymerase delta auxiliary protein
- MGC8367
- proliferating cell nuclear antigen
Background
PCNA is a marker for cells in early G1 phase and S phase of the cell cycle. It is found in the nucleus and is a cofactor of DNA polymerase delta. PCNA acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, PCNA is ubiquitinated and is involved in the RAD6 dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for PCNA. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.
