PON2 Antibody Summary
| Immunogen |
Peptide with sequence C-EKPRARELRIS corresponding to internal region according to NP_000296.2, NP_001018171.1.
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| Epitope |
C-EKPRARELRIS
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| Specificity |
This antibody is expected to recognize isoforms 1 and 2 (NP_000296.2; NP_001018171.1).
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
PON2
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Approx. 40 kDa band double band observed in lysates of HepG2 (calculated MW of 39.4 kDa band according to NP_000296.2 and of 38.0 kDa band according to NP_001018171.1). An additional band of unknown identity was also consistently observed at 60 kDa. This band was successfully blocked by incubation with the immunizing peptide.
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Rat, Porcine, Canine.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
|
| Preservative |
0.02% Sodium Azide
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| Concentration |
0.5 mg/ml
|
| Purity |
Immunogen affinity purified
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Alternate Names for PON2 Antibody
- A-esterase 2
- Aromatic esterase 2
- EC 3.1.1.2
- EC 3.1.1.81
- paraoxonase 2
- paraoxonase nirs
- PON 2
- PON2
- Serum Aryldialkylphosphatase 2
- serum paraoxonase/arylesterase 2
Background
This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.
