PPAR gamma/NR1C3 Antibody Summary
| Immunogen |
Synthetic peptide from human PPARG.
|
| Specificity |
A region near the amino terminus of human PPAR gamma 2.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
PPARG
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Macque
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
20mM Potassium Phosphate (pH 7.2) and 0.15M NaCl
|
| Preservative |
0.01% Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for PPAR gamma/NR1C3 Antibody
- CIMT1
- NR1C3
- NR1C3GLM1
- Nuclear receptor subfamily 1 group C member 3
- peroxisome proliferator-activated receptor gamma 1
- peroxisome proliferator-activated receptor gamma
- PPAR gamma
- PPARG
- PPARG1peroxisome proliferative activated receptor, gamma
- PPARG2PPARgamma
- PPAR-gamma
Background
Since their discovery in the early 1990s, the peroxisome proliferator activated receptors (PPARs) have attracted significant attention. This is primarily because PPARs serve as receptors for two very important classes of drugs: the hypolipidemic fibrates and the insulin sensitizing thiazolidinediones. Peroxisome proliferators are non-genotoxic carcinogens that are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed PPARs. Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Upon binding fatty acids or hypolipidemic drugs, PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate the expression of target genes. There are 3 known subtypes of PPARs: PPAR-alpha, PPAR-delta and PPAR-gamma. The target genes of PPAR-alpha and PPAR-delta are primarily involved in the catabolism of fatty acids. Conversely, PPAR-gamma is activated by peroxisome proliferators such as prostaglandins, leukotrienes and anti-diabetic thiazolidinediones and affects the expression of genes involved in the storage of fatty acids. PPAR-gamma may also be involved in adipocyte differentiation. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase and cytochrome P450 through interaction with specific response elements.
