PTP rho/PTPRT Antibody Summary
| Immunogen |
The immunogen for this antibody was a sequence from 383a.a. to 484a.a. from PTP rho(a 1444a.a. long protein)
|
| Localization |
Membrane; single-pass type I membrane protein.
|
| Specificity |
PTP rho
|
| Clonality |
Polyclonal
|
| Host |
Chicken
|
| Gene |
PTPRT
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000. Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development.
|
Reactivity Notes
This antibody is reactive against Human, rat.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
No Preservative
|
| Purity |
Immunogen affinity purified
|
Alternate Names for PTP rho/PTPRT Antibody
- EC 3.1.3
- EC 3.1.3.48
- KIAA0283RPTPrho
- protein tyrosine phosphatase, receptor type, T
- PTP rho
- PTPRT
- receptor protein tyrosine phosphatase
- Receptor-type tyrosine-protein phosphatase rho
- receptor-type tyrosine-protein phosphatase T
- RPTP-rho
- R-PTP-T
Background
PTP rho is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP rho is a large protein that possesses a PTP domain at the C-terminus, and multiple noncatalytic domains, which include a domain with similarity to the band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. PTP rho interacts with, and dephosphorylates, Fas receptor, as well as I-kappa B-alpha through the PDZ domains, which suggests that it may have a role in Fas-mediated programmed cell death. PTP rho also interacts with GTPase-activating protein, and thus may function as a regulator of the Rho signaling pathway. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.May be involved in both signal transduction and cellular adhesion in the CNS.
