PXR/NR1I2 Antibody Summary
| Immunogen |
Peptide with sequence EQFAITLKSYIECNR corresponding to internal region according to NP_003880.3, NP_071285.1, NP_148934.1.
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| Epitope |
internal region
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| Specificity |
This antibody is expected to recognize all reported isoforms (NP_071285.1; NP_148934.1; NP_003880.3).
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
NR1I2
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Approx. 48 kDa band observed in HepG2 lysates (calculated MW of 49.8 kDa band according to NP_003880.3). An additional band of unknown identity was also consistently observed at 35 kDa. This band was successfully blocked by incubation with the immunizing peptide.
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| Publications |
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Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
0.5 mg/ml
|
| Purity |
Immunogen affinity purified
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Alternate Names for PXR/NR1I2 Antibody
- BXR
- NR1I2
- nuclear receptor subfamily 1 group I member 2
- nuclear receptor subfamily 1, group I, member 2
- ONR1
- Orphan nuclear receptor PAR1
- Orphan nuclear receptor PXR
- PAR
- PAR1
- PAR2
- Pregnane X receptor
- PRR
- PXR
- PXRPARq
- SAR
- Steroid and xenobiotic receptor
- SXR
- SXRBXR
Background
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq]
