Product: Methoxyphenamine (Hydrochloride)
Pappalysin-1/PAPP-A Antibody (10H9) Summary
| Immunogen |
Purified human PAPPA antigen.
|
| Specificity |
PAPPA (10H9)
|
| Isotype |
IgG2a
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
PAPPA
|
| Purity |
Protein A purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Recommended pairs for the detection of dPAPP-A antigen in blood of AMI patients and patients with unstable angina (capture – detection): NB200-401 – NB200-404.Best pairs for the detection of htPAPP-A antigen in pregnancy serum (capture – detection): NB200-401 – NB200-404.
|
Reactivity Notes
Cross-reacts with Human. Not yet tested in other species.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
0.09% Sodium Azide
|
| Purity |
Protein A purified
|
Alternate Names for Pappalysin-1/PAPP-A Antibody (10H9)
- ASBABP2
- DIPLA1
- EC 3.4.24.79
- IGFBP-4ase
- IGFBP-4aseaspecific BCL2 ARE-binding protein 2
- IGF-dependent IGFBP-4 protease
- insulin-like growth factor-dependent IGF binding protein-4 protease
- Insulin-like growth factor-dependent IGF-binding protein 4 protease
- PAPA
- PAPPA
- PAPPA1
- PAPP-A1
- PAPP-Adifferentially placenta 1 expressed protein
- Pappalysin1
- Pappalysin-1
- pregnacy-associated plasma protein A
- Pregnancy-associated plasma protein A
- pregnancy-associated plasma protein A, pappalysin 1
Background
PAPP A was originally isolated from pregnancy serum as heterotetrameric protein complex with molecular weight approximately 500 kDa, consisting of two PAPP A subunits disulfide-linked with two subunits of the proform of eosinophil major basic protein (proMBP). In such a complex proMBP functions as an inhibitor of PAPP A proteinase activity. PAPP A is widely used as a marker of some pathologies during pregnancy. Reduced level of PAPP A in pregnancy blood in the first trimester is associated with fetal Down syndrome. PAPP A is considered as one of the best biochemical markers in early pregnancy used to screen for Down syndrome during the first trimester (Wald, N. J. et al).
