Progesterone R/NR3C3 Antibody (4D8) Summary
| Immunogen |
The region encoding amino acids 1-101 of the human progesterone receptor expressed in E. coli.
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| Specificity |
This antibody will recognize human PgR.
|
| Isotype |
IgG2a
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| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
PGR
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
No Preservative
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Progesterone R/NR3C3 Antibody (4D8)
- NR3C3
- NR3C3PRNuclear receptor subfamily 3 group C member 3
- PGR
- Progesterone R
- progesterone receptor
- ProgesteroneR
Background
The human Progesterone Receptor (PgR) is a member of the steroid family of nuclear receptors. PgR is found as a 120 kDa protein (Form B) or a 94 kDa protein (Form A) due to the use of alternative translation initiation sites. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. When bound to DNA, PgR can positively or negatively regulate gene transcription through the recruitment of coactivator (e.g. SRC-1) or corepressor (e.g. NCoR) proteins.
