Proteinase 3/Myeloblastin/PRTN3 Antibody (3B4) Summary
| Immunogen |
Purified recombinant fragment of human Proteinase 3 expressed in E. Coli.
|
| Isotype |
IgG2b
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
PRTN3
|
| Purity |
Protein G purified
|
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|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS and 50% Glycerol
|
| Preservative |
0.03% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein G purified
|
Alternate Names for Proteinase 3/Myeloblastin/PRTN3 Antibody (3B4)
- ACPA
- AGP7
- AGP7PR3
- azurophil granule protein 7
- C-ANCA
- EC 3.4.21
- EC 3.4.21.76
- Leukocyte proteinase 3
- MBN
- MBT
- Myeloblastin
- Neutrophil proteinase 4
- NP4
- NP-4
- P29C-ANCA antigen
- PR-3CANCA
- Proteinase 3
- PRTN3
- serine proteinase, neutrophil
- Wegener autoantigen
- Wegener granulomatosis autoantigen
Background
Myeloblastin (PR3) is a polymorphonuclear leukocyte serine protease which degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters. PR3 plays a role in neutrophil response to inflammation.
