Product: CHIR-99021 (trihydrochloride)
ROCK1 Antibody Summary
| Immunogen |
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human ROCK1. The exact sequence is proprietary.
|
| Localization |
Cytoplasm; Centrosome; centriole (By similarity); Golgi apparatus membrane; Peripheral membrane protein
|
| Predicted Species |
Mouse (100%), Rat (100%), Monkey (100%), Rabbit (100%). Backed by our 100% Guarantee.
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
ROCK1
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
| Theoretical MW |
158 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Rhesus Monkey (100%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.0) and 20% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for ROCK1 Antibody
- EC 2.7.11
- EC 2.7.11.1
- MGC131603
- MGC43611
- p160 ROCK-1
- p160ROCK
- p160-ROCK
- PRO0435
- Renal carcinoma antigen NY-REN-35
- Rho kinase
- rho-associated protein kinase 1
- Rho-associated, coiled-coil containing protein kinase 1
- Rho-associated, coiled-coil-containing protein kinase 1
- ROCK1
- ROK beta
Background
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq]
