Recombinant Human Prohibitin 2 Protein Summary
| Description |
A denatured recombinant protein with a His tag corresponding to amino acids 1 – 299 of PHB2.
Source: E.coli Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSMAQNLKD LAGRLPAGPR GMGTALKLLL GAGAVAYGVR ESVFTVEGGH RAIFFNRIGG VQQDTILAEG LHFRIPWFQY PIIYDIRARP RKISSPTGSK DLQMVNISLR VLSRPNAQEL PSMYQRLGLD YEERVLPSIV NEVLKSVVAK FNASQLITQR AQVSLLIRRE LTERAKDFSL ILDDVAITEL SFSREYTAAV EAKQVAQQEA QRAQFLVEKA KQEQRQKIVQ AEGEAEAAKM LGEALSKNPG YIKLRKIRAA QNISKTIATS QNRIYLTADN LVLNLQDESF TRGSDSLIKG KK |
| Protein/Peptide Type |
Recombinant Protein
|
| Gene |
PHB2
|
| Purity |
>85%, by SDS-PAGE
|
Applications/Dilutions
| Theoretical MW |
35.7 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
|
| Preservative |
No Preservative
|
| Concentration |
1 mg/ml
|
| Purity |
>85%, by SDS-PAGE
|
Alternate Names for Recombinant Human Prohibitin 2 Protein
- BAP
- Bap37
- BCAP37
- B-cell associated protein
- D-Prohibitin
- MGC117268
- p22
- PHB2
- PNAS-141
- Prohibitin 2
- prohibitin-2
- REA
- REAB-cell receptor-associated protein BAP37
- Repressor of estrogen receptor activity
Background
prohibitin 2 Protein acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases by similarity. This protein functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. prohibitin 2 Protein competes with NCOA1 for modulation of ER transcriptional activity. It is probably involved in regulating mitochondrial respiration activity and in aging. Recombinant human prohibitin 2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
