Recombinant Human Substance P Protein Summary
| Description |
A denatured recombinant protein with a His tag corresponding to amino acids 20 – 129 of TAC1.
Source: E.coli Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMEEIGA NDDLNYWSDW YDSDQIKEEL PEPFEHLLQR IARRPKPQQF FGLMGKRDAD SSIEKQVALL KALYGHGQIS HKRHKTDSFV GLMGKRALNS VAYERSAMQN YERRR |
| Protein/Peptide Type |
Recombinant Protein
|
| Gene |
TAC1
|
| Purity |
>95% pure by SDS-PAGE
|
Applications/Dilutions
| Theoretical MW |
15.6 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 2M urea
|
| Preservative |
No Preservative
|
| Concentration |
1 mg/ml
|
| Purity |
>95% pure by SDS-PAGE
|
Alternate Names for Recombinant Human Substance P Protein
- neurokinin 1
- neurokinin 2
- neurokinin A
- Neurokinin-1
- neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
- neuropeptide gamma
- neuropeptide K
- NK2
- NKA
- NKNAneurokinin alpha
- NPK
- PPT
- protachykinin-1
- substance K
- Substance P
- TAC2neuromedin L
- tachykinin 2
- tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2
- tachykinin, precursor 1
Background
TAC1, also known as protachykinin 1, is a member of the tachykinin peptide hormone family. TAC1 are a family of peptides that have similar biologic activities and share a common C-terminal sequence, phe-X-gly-leu-met-NH2, but have distinct N-terminal sequences that convey receptor specificities. TAC1 is thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. It is known to induce behavioral responses and function as vasodilators and secretagogues. Recombinant human TAC1 protein, fused to His-tag at N-terminus, was expressed in E.coli.
