SIM2 Antibody Summary
| Immunogen |
Peptide with sequence C-SDLLYTPSYS corresponding to internal region according to NP_033664.2.
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| Epitope |
C-SDLLYTPSYS
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| Specificity |
This antibody is expected to recognize all reported isoforms (NP_005060.1; NP_033664.2).
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
SIM2
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Approx. 80 kDa band observed in fetal mouse kidney lysates (calculated MW of 73.2 kDa band according to human NP_005060.1) and 72.5 kDa band according to mouse NP_035507.2.
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Human, Rat.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
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| Preservative |
0.02% Sodium Azide
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| Concentration |
0.5 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for SIM2 Antibody
- human transcription factor SIM2, homolog of the Drosophila single-minded geneSIM110BHLHE15
- short isoform
- single-minded (Drosophila) homolog 2
- single-minded homolog 2 (Drosophila)
- transcription factor SIM2
Background
SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. The Drosophila sim gene encodes a transcription factor that is a master regulator of fruit fly neurogenesis. SIM2 maps within the so-called Down syndrome chromosomal region. Based on the mapping position, its potential function as transcriptional repressor and similarity to Drosophila sim, it is proposed that SIM2 may contribute to some specific Down syndrome phenotypes
